請問這份 Sysctl 配置究竟存在什麼問題？

疑問背景：
前些日子小團隊請了專業的工程師來幫忙提升用作 PROXY 用途伺服器上的網路效能，經過對相應程式和系統的優化，的確是將現有帶寬利用至相當充分。
之前數據庫伺服器上也存在相應的網路效能問題，於是不懂技術的成員就在搜索引擎上查了一下，就想當然地把那臺機器上的 sysctl.conf 搬到了這臺機器上來。
隨之而來新的問題就出現了，帶寬利用率雖然是達到了相當好的水平，但是 Mysql 處理效能卻下降了不少，並且延時有時高到了無法接受的水準。

想問的問題：
所以這份配置究竟存在什麼問題？如果知道問題出自於哪又應當如何修改？
希望熟悉的人可以幫幫忙，在這先謝謝大家了。

附配置檔：

kernel.sysrq = 0
kernel.panic = 1
kernel.watchdog = 0

net.core.default_qdisc = cake
net.core.netdev_max_backlog = 4096
net.core.rmem_max = 4000000
net.core.rmem_default = 4000000
net.core.wmem_max = 4000000
net.core.wmem_default = 4000000
net.core.somaxconn = 256

net.ipv4.tcp_congestion_control = bbr
net.ipv4.tcp_keepalive_time = 600
net.ipv4.tcp_keepalive_intvl = 200
net.ipv4.tcp_keepalive_probes = 3
net.ipv4.tcp_syncookies = 1
net.ipv4.tcp_sack = 1
net.ipv4.ip_no_pmtu_disc = 0
net.ipv4.tcp_mtu_probing = 1
net.ipv4.tcp_base_mss = 1024
net.ipv4.tcp_ecn = 1
net.ipv4.tcp_ecn_fallback = 1
net.ipv4.tcp_max_syn_backlog = 4096
net.ipv4.tcp_fastopen = 0
net.ipv4.tcp_timestamps = 0
net.ipv4.tcp_tw_reuse = 0
net.ipv4.tcp_syn_retries = 3
net.ipv4.tcp_synack_retries = 3
net.ipv4.tcp_retries1 = 3
net.ipv4.tcp_retries2 = 3
net.ipv4.tcp_fin_timeout = 3
net.ipv4.tcp_max_tw_buckets = 65535
net.ipv4.ip_default_ttl = 255
net.ipv4.tcp_window_scaling = 1
net.ipv4.conf.all.rp_filter = 2
net.ipv4.conf.default.rp_filter = 2
net.ipv4.tcp_low_latency = 1
net.ipv4.ip_forward = 1
net.ipv4.ip_early_demux = 0
net.ipv4.tcp_no_metrics_save = 1
net.ipv4.tcp_orphan_retries = 2
net.ipv4.tcp_min_tso_segs = 2
net.ipv4.tcp_tso_win_divisor = 2
net.ipv4.tcp_moderate_rcvbuf = 1
net.ipv4.tcp_adv_win_scale = 2
net.ipv4.tcp_slow_start_after_idle = 0
net.ipv4.tcp_comp_sack_delay_ns = 1000000
net.ipv4.tcp_rfc1337 = 1
net.ipv4.tcp_early_demux = 0
net.ipv4.udp_early_demux = 0
net.ipv4.tcp_recovery = 1
net.ipv4.tcp_frto = 2
net.ipv4.tcp_min_rtt_wlen = 50
net.ipv4.tcp_reordering = 6
net.ipv4.ipfrag_time = 60
net.ipv4.ping_group_range= 0 10
net.ipv4.route.min_adv_mss = 1024
net.ipv4.route.gc_min_interval_ms = 200

net.ipv6.conf.all.forwarding = 1
net.ipv6.conf.all.accept_ra = 2
net.ipv6.conf.all.proxy_ndp = 1
net.ipv6.conf.all.hop_limit = 128
net.ipv6.conf.default.hop_limit = 128
net.ipv6.route.min_adv_mss = 1024
net.ipv6.route.mtu_expires = 600
net.ipv6.ip6frag_time = 60
net.ipv6.route.gc_min_interval_ms = 200

vm.swappiness = 100
vm.vfs_cache_pressure = 200
vm.dirty_writeback_centisecs = 500
vm.dirty_expire_centisecs = 1000
vm.dirty_ratio = 4
vm.dirty_background_ratio = 2
vm.min_free_kbytes = 150000
vm.max_map_count = 262144
vm.page-cluster = 4
vm.zone_reclaim_mode = 2
vm.dirtytime_expire_seconds = 21600
vm.overcommit_memory = 0
vm.overcommit_ratio = 25
vm.extfrag_threshold = 10
vm.memory_failure_early_kill = 1

fs.aio-max-nr = 1048576
fs.lease-break-time = 15

net.nf_conntrack_max = 1024576
net.netfilter.nf_conntrack_buckets = 32768
net.netfilter.nf_conntrack_tcp_timeout_established = 3600
net.netfilter.nf_conntrack_sctp_timeout_established = 3600
net.netfilter.nf_conntrack_dccp_timeout_open = 3600