* Pricing is extremely high now if you got decent traffic and almost cannot be optimized due your site's dynamic nature.
* Average latency could be greater than 100 ms, if you have several queries on one page, latency could go up to 500 or even 1000 ms.
* In order to max out memcache, you need to transform your design mindset: memcache will be the 1st class citizen in your app design, that means you need to put extra efforts to plan usage of memcache, yes a lot of extra efforts.
* Remember: it can't really help you on traffic spike unless you have set a high enough daily budget, so you may get 503 errors before you can serve traffic spike.
* Remember: in a start-up world means you need to worry about present, not future. Present is about how fast you can change and implement new features.
Way to go:
http://www.linode.com/?r=af313ea8a6bb6f99aff800c67349cabbfee2682f
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https://www.v2ex.com/t/21036
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