Ag-RDTs are less sensitive than RT-PCR, but clinical evaluation data is emerging that demonstrates Ag-RDTs are accurate at detecting the vast majority of individuals with a high-viral load (cycle threshold (Ct) on RT-PCR ≤ 25.0 or > 106 genomic virus copies/ml) https://www.nature.com/articles/s41598-021-97489-9#ref-CR18