FRANCHISES
- Sabrina the Teenage Witch
- Sailor Moon
- Saint Seiya
- Sakura Wars
- Salamander
- Samurai Jack
- Samurai Shodown
- San Francisco Rush
- Sanrio
- Saturday Night Slam Masters / Muscle Bomber
- Scooby-Doo!
- Scorpion King
- Scrabble
- SD Gundam
- SD Gundam Gaiden
- SeaWorld
- Sega Rally
- Sega Smash Pack
- Sensible Soccer
- Serious Sam
- Sesame Street
- Shadow Man
- Shadow of the Beast
- Shadowgate
- Shadowrun
- Shaman King
- Shantae
- Shark Tale
- Shaun Palmer's Snowboard
- Sheep
- Sherlock Holmes
- Shikakui Atama o Maru Kusuru
- Shin Megami Tensei
- Shin Megami Tensei: Devil Children
- Shining
- Shining Force
- Shining Soul
- Shinobi
- Shinri Game
- Shinseiki GPX Cyber Formula
- Shogun
- Shounen Jump
- Shrek
- Side Pocket
- Silent Hill
- Silent Scope
- Silkworm / SWIV
- SimCity
- Simpsons
- Sister Princess
- Skate or Die
- Slam Dunk
- Slayers
- Slot! Pro
- Small Soldiers
- Smash Bros.
- Smash T.V.
- Smuggler's Run
- Smurfs
- Snood
- Snowboard Kids
- Solomon's Key
- Sonic Blast Man
- Sonic the Hedgehog
- Sorcerian
- Sotsugyou: Graduation
- Soukoban
- South Park
- Space Ace
- Space Channel 5
- Space Harrier
- Space Invaders
- Spawn
- Speed Racer
- Speedball
- Speedy Gonzales
- Spelunker
- Spider-Man
- Spindizzy
- Spirou
- Splatterhouse
- SpongeBob Squarepants
- Sports Illustrated
- Spot
- Spy Hunter
- Spy Kids
- Spy vs. Spy
- Spyro the Dragon
- SSX
- Star Control
- Star Fox
- Star Ocean
- Star Soldier
- Star Trek
- Star Wars
- Starcraft
- Starfy
- Starsky & Hutch
- Strawberry Shortcake
- Street Fighter
- Street Fighter Alpha
- Streets of Rage
- Strider
- Stuart Little
- Suikoden
- Summon Night
- Super Chinese
- Super Collapse
- Super Monkey Ball
- Super Real Mahjong
- Super Robot Wars
- Super Sentai
- Super Shogi
- Supercross
- Superman
- Syndicate